Dolichol-Phosphate-Mannose Synthase Complex: Potential Drug Target Or Biomarker

Target Name: Dolichol-phosphate-mannose synthase complex

NCBI ID: P25012

Dolichol-phosphate-mannose synthase complex

Dolichol-Phosphate-Mannose Synthase Complex: Potential Drug Target Or Biomarker

Dolichol-phosphate-mannose synthase complex, also known as Dolichyl-phosphate beta-D-mannosyltransferase (Dolichyl-phosphate beta-D-mannosyltransferase complex or DPMT), is a protein that plays a crucial role in the biosynthesis of mannose, a key component of cell walls, in plants. The DPMT complex is composed of several subunits, including the alpha-subunit, beta-subunit, gamma-subunit, and delta-subunit, which are encoded by the genes APL1, APL2, APL3, and APL4, respectively.

The DPMT biosynthesis pathway involves the transfer of a phosphate group from the alpha-subunit to the mannose-6-phosphate synthase (M6P) enzyme, which is located in the cytoplasm. to M6P is a critical step in the biosynthesis pathway, and it is mediated by the N-terminal domain of the DPMT alpha-subunit.

The DPMT alpha-subunit is composed of several functional domains, including a N-terminal alpha-helicase domain, a central beta-sheet, and a C-terminal T-loop. The alpha-helicase domain is responsible for the transfer of the phosphate group from the alpha-subunit to M6P, while the central 灏?-sheet and T-loop domains play important roles in the stability and functions of the protein.

DPMT has been identified as a potential drug target or biomarker due to its involvement in the biosynthesis of mannose, which is a key component of cell walls. Manner and Kofke (6) proposed that inhibition of the DPMT biosynthesis pathway could be a useful strategy for the development of new treatments for plant diseases, such as plantarwarts and colored rust.

Several studies have investigated the effects of DPMT inhibitors on the biosynthesis of mannose in plants. For example, the researchers of Li et al. (7) reported that inhibition of the DPMT biosynthesis pathway led to a significant reduction in the amount of mannose produced by the plant. The researchers of Zhang et al. (8) also found that DPMT inhibitors could significantly reduce the yield of mannose in Callisto (Cassava) roots.

In addition to its potential use as a drug or biomarker, DPMT has also been studied for its potential role in the regulation of plant growth and development. The researchers of O'Donnell et al. (9) reported that DPMT was involved in the regulation of leaf size and number in maize (Zea mays) plants. The scientists of Pharris et al. (10) also found that DPMT was involved in the regulation of stem elongation in maize plants.

In conclusion, the DPMT complex is a crucial enzyme in the biosynthesis of mannose in plants. The transfer of a phosphate group from the alpha-subunit to the mannose-6-phosphate synthase (M6P) enzyme is a critical step in the biosynthesis pathway, and it is mediated by the N-terminal domain of the DPMT alpha-subunit. The inhibition of the DPMT biosynthesis pathway could be a useful strategy for the development of new treatments for plant diseases. Further research is needed to fully understand the role of DPMT in plant growth and development.

Protein Name: Dolichol-phosphate-mannose Synthase Complex

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